Based on the press release of Dr. Isti Anindya, S.Si., M.Sc
A recent study by Isti Anindya, an autism researcher from the Faculty of Medicine, University of Indonesia (FK UI), revealed important findings related to the role of Cytomegalovirus (CMV) in increasing IL-6 and IL-1β levels, which have an impact on sensory profiles and eating behavior in autistic children. This scientific publication has been published in the journal Biomedicines with the title “Cytomegalovirus-Reactive IgG Correlates with Increased IL-6 and IL-1β Levels, Affecting Eating Behaviors and Tactile Sensitivity in Children with Autism” (https://www.mdpi.com/2227-9059/13/2/338). In her interview, Isti Anindya explained that this study is the first in Indonesia to reveal the relationship between CMV and increased pro-inflammatory cytokines, which have the potential to affect sensory regulation and eating behavior in autistic children. With a cross-sectional study design, this study involved 98 autistic children and 96 neurotypical children as a control group. Data collected included CMV IgG levels, IL-6, IL-1β, as well as eating behavior scores and sensory profiles assessed using BAMBI (Brief Autism Mealtime Behaviors Inventory) and Short Sensory Profile (SSP).
“The results of our study show a significant correlation between CMV IgG and IL-6 and IL-1β in autistic children, which then impacts their eating patterns and sensory sensitivity. This is an initial step to understanding the role of latent infection in the manifestation of autism symptoms,” said Isti Anindya.
This finding has received widespread attention in the scientific community, as it can open up new opportunities for a more holistic clinical approach in treating autism. This study also highlights the importance of CMV screening as part of the health evaluation of autistic children.In addition to being active in research, Isti Anindya is also known as an autism awareness activist who often shares her scientific insights with the public. Her name has appeared several times in national media, including in coverage by Detik Health and Detik Edu, which highlighted her contribution to autism research. She is also currently establishing PT. Peduli Autisme Indonesia, the first edtech startup in Indonesia that focuses on autism education.
Welcoming World Autism Day on April 2, 2025, Isti invites stakeholders, academics, and the wider community to participate in the autism awareness campaign. “With a better understanding of the biological factors that influence autism, we can create a more inclusive environment and provide more targeted support,” she added.