My main research in the last few years in Japan is about cell to cell and cell to ECM communication in Pituitary gland. The main ECM studied is the proteoglycan in pituitary gland, especially SLRPs. ECM is shown to regulate the pitutary’s cells communication and the synthesis of ECM, GF and hormone. I just started my research in Indonesia in 2020, using the same SLRPs, I am studying about this cell’s communication in wound healing process. SLRPs is associated with collagen fibril formation and play roles in wound healing process. Thus, SLRPs can be further studied as a potential candidate for cutaneous wound healing management